Lebensmitteltechnologie und Ernährung Center of Excellence

Publikationen

Peer Reviewed

2022

  • Nicole Ollinger, Alexandra Malachova, Michael Sulyok, Lisa Schütz-Kapl, Nicole Wiesinger, Rudolf Krska, Julian Weghuber (2022)  Combination of DNA barcoding, targeted metabolite profiling and multispectral imaging to identify mould species and metabolites on sliced bread Future Foods 6: 100196.
  • Florencia Sánchez, Marina Dietz, Ulrike Müller, Julian Weghuber, Karl Gatterdam, Ralph Wieneke, Mike Heilemann, Peter Lanzerstorfer, Robert Tampé (2022)  Dynamic in Situ Confinement Triggers Ligand-Free Neuropeptide Receptor Signaling Nano Letters In press.
  • Bernhard Blank-Landeshammer, Gerald Klanert, Lisa Mitter, Sophia Turisser, Nicolas Nusser, Alice König, Marcus Iken, Julian Weghuber (2022)  Improved Bioavailability and Bioaccessibility of Lutein and Isoflavones in Cultured Cells In Vitro through Interaction with Ginger, Curcuma and Black Pepper Extracts Antioxidants 11:  1917.
  • Mara Heckmann, Nadiia Sadova, Ivana Drotarova, Stefanie Atzmüller, Bettina Schwarzinger, Roberto Mauricio Carvalho Guedes, Paula Angelica Correia, Stefan Hirtenlehner, Christine Potthast, Gerald Klanert, Julian Weghuber (2022)  Extracts Prepared from Feed Supplements Containing Wood Lignans Improve Intestinal Health by Strengthening Barrier Integrity and Reducing Inflammation Molecules 27:  6327. 
  • Roland Hager, Christian Forsich, Jiri Duchoslav, Christoph Burgstaller, David Stifter, Julian Weghuber, Peter Lanzerstorfer (2022)  Microcontact Printing of Biomolecules on Various Polymeric Substrates: Limitations and Applicability for Fluorescence Microscopy and Subcellular Micropatterning Assays ACS Applied Polymer Materials In press
  • Bettina Schwarzinger, Michaela Feichtinger, Bernhard Blank-Landeshammer, Julian Weghuber, Clemens Schwarzinger (2022)  Quick determination of erucic acid in mustard oils and seeds Journal of Analytical and Applied Pyrolysis April: 105523. 
  • Nicole Ollinger, Cathrina Neuhauser, Bettina Schwarzinger, Melanie Wallner, Clemens Schwarzinger, Bernhard Blank-Landeshammer, Roland Hager, Nadiia Sadova, Ivana Drotarova, Katrin Mathmann, Eugenia Karamouzi, Panagiotis Panopoulos, Gerald Rimbach, Kai Lüersen, Julian Weghuber, Clemens Röhrl (2022)  Anti-hyperglycemic effects of oils and extracts derived from sea buckthorn - a comprehensive analysis utilizing in-vitro and in-vivo models Molecular Nutrition & Food Research 2101133: .
  • Cindy Dirscherl, Sara Loechte, Zeynep Hein, Janine-Denise Kopicki, Antonia Regina Harders, Noemi Linden, Julian Weghuber, Maria Garcia-Alai, Charlotte Uetrecht, Martin Zacharias, Jacob Piehler, Peter Lanzerstorfer, Sebastian Springer (2022)  Dissociation of β2m from MHC Class I Triggers Formation of Noncovalent, Transient Heavy Chain Dimers Journal of Cell Science April 22:  259498. 
  • Tina Karimian, Roland Hager, Andreas Karner, Julian Weghuber, Peter Lanzerstorfer (2022)  A simplified and robust activation procedure of glass surfaces for printing proteins and subcellular micropatterning experiments Biosensors 12:  140. 
  • Mara Heckmann, Gerald Klanert, Georg Sandner, Peter Lanzerstorfer, Manfred Auer, Julian Weghuber (2022)  Fluorescence Microscopy-Based Quantitation of GLUT4 Translocation Methods and Applications in Fluorescence 10: 022001

2021

  • Ilka Günther, Gerald Rimbach, Sandra Nevermann, Cathrina Neuhauser, Verena Stadlbauer, Bettina Schwarzinger, Clemens Schwarzinger, Ignacio R Ipharraguerre, Julian Weghuber, Kai Lüersen (2021)  Avens root (Geum urbanum L.) extract discovered by target-based screening exhibits antidiabetic activity in the hen’s egg test model and Drosophila melanogaster Frontiers in  Pharmacology 12:  794404. 
  • Roland Hager, Ulrike Müller, Nicole Ollinger, Julian Weghuber, Peter Lanzerstorfer (2021)  Subcellular dynamic immunopatterning of cytosolic protein complexes on microstructured polymer substrates ACS Sensors 6: 11. 4076-4088
  • Clemens Röhrl, Stefanie Steinbauer, Raimund Bauer, Eva Roitinger, Katharina Otteneder, Melanie Wallner, Cathrina Neuhauser, Bettina Schwarzinger, Clemens Schwarzinger, Herbert Stangl, Marcus Iken, Julian Weghuber (2021)  Aqueous extracts of lingonberry and blackberry leaves identified by high-content screening beneficially act on cholesterol metabolism Food and Function 12:  21.  10432-10442.
  • Roland Hager, Johannes Pitsch, Jakob Kerbl-Knapp, Cathrina Neuhauser, Nicole Ollinger, Marcus Iken, Josef Ranner, Verena Mittermeier-Kleßinger, Corinna Dawid, Peter Lanzerstorfer, Julian Weghuber (2021)  A high-content screen for the identification of plant extracts with insulin secretion-modulating activity Pharmaceuticals 14:  809.
  • Verena Stadlbauer, Cathrina Neuhauser, Tobias Aumiller, Alexander Stallinger, Marcus Iken, Julian Weghuber (2021)  Identification of insulin mimetic plant extracts: from an in vitro high-content screen to blood glucose reduction in live animals Molecules 26:  4346.
  • Verena Richter, Peter Lanzerstorfer, Julian Weghuber, Herbert Schneckenburger (2021)  Probing small distances in live cell imaging Photonics 8:  176. 
  • Johannes Pitsch, Georg Sandner, Jakob Huemer, Maximilian Huemer, Stefan Huemer, Julian Weghuber (2021)  FODMAP Fingerprinting of Bakery Products and Sourdoughs: Quantitative Assessment and Content Reduction Through Fermentation Foods 10(4):  894.
  • Christoph Eilenberger, Mario Rothbauer, Florian Selinger, Anna Gerhartl, Christian Jordan, Michael Harasek, Barbara Schädl, Johannes Grillari, Julian Weghuber, Winfried Neuhaus, Seta Küpcü, Peter Ertl (2021)  A microfluidic multi-size spheroid array for multi-parametric screening of anti-cancer drugs and blood-brain barrier transport properties Advanced Science 2021:  2004856. 
  • Georg Sandner, Alice König, Melanie Wallner, Julian Weghuber (2021)  Alternative model organisms for toxicological fingerprinting of relevant parameters in food and nutrition Critical Reviews in Food Science and Nutrition Mar 8:  1-18.
  • Peter Lanzerstorfer, Georg Sandner, Johannes Pitsch, Julian Weghuber (2021)  Acute, reproductive, and developmental toxicity of essential oils assessed with alternative in vitro and in vivo systems Archives of Toxicology 95:  2.  673–691. 
  • Aurelia TSCHIDA, Verena STADLBAUER, Bettina SCHWARZINGER, Martin MAIER, Johannes PITSCH, Flora STÜBL, Ulrike MÜLLER, Peter LANZERSTORFER, Markus HIMMELSBACH, Jürgen WRUSS, Gerald KLANERT, Jonas SCHURR, Lothar WURM, Franz ROSNER, Otmar HÖGLINGER, Stephan WINKLER, Julian WEGHUBER (2021)  Nutrients, bioactive compounds, and minerals in the juices of 16 varieties of apple (Malus domestica) harvested in Austria: A four-year study investigating putative correlations with weather conditions during ripening Food Chemistry 338:  128065. 

2020

  • Verena Stadlbauer, Peter Lanzerstorfer, Cathrina Neuhauser, Florian Weber, Flora Stübl, Petra Weber, Michael Wagner, Birgit Plochberger, Stefan Wieser, Herbert Schneckenburger, Julian Weghuber (2020)  Fluorescence microscopy-based quantitation of GLUT4 translocation: high-throughput or high-content? International Journal of Molecular Sciences 21:  21.  7964. 
  • Valeria Venturini, Fabio Pezzano, Frederic Català Castro, Hanna-Maria Häkkinen, Senda Jiménez-Delgado, Mariona Colomer-Rosell, Monica Marro, Queralt Tolosa-Ramon, Sonia Paz-López, Miguel A Valverde, Julian Weghuber, Pablo Loza-Alvarez, Michael Krieg, Stefan Wieser, Verena Ruprecht (2020)  The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior Science 370:  6514. 
  • Georg Sandner, Alice König, Melanie Wallner, Julian Weghuber (2020)  Functional foods - dietary or herbal products on obesity - Application of selected bioactive compounds to target lipid metabolism Current Opinion in Food Science 36
  • Verena Richter, Peter Lanzerstorfer, Julian Weghuber, Herbert Schneckenburger (2020)  Super-Resolution Live Cell Microscopy of Membrane-Proximal Fluorophores International Journal of Molecular Sciences 21:  19. 
  • Georg Sandner, Mara Heckmann, Julian Weghuber (2020)  Immunomodulatory Activities of Selected Essential Oils Biomolecules 10:  8. 
  • Johannes Pitsch, Otmar Höglinger, Julian Weghuber (2020)  Roasted Rye as a Coffee Substitute: Methods for Reducing Acrylamide Foods 9:  7.  
  • Peter Lanzerstorfer, Ulrike Müller, Julian Weghuber, Christof M Niemeyer (2020)  Highly Modular Protein Micropatterning Sheds Light on the Role of Clathrin-Mediated Endocytosis for the Quantitative Analysis of Protein-Protein Interactions in Live Cells Biomolecules 10:  4. 
  • Nicole Ollinger, Verena Lasinger, Claudia Probst, Johannes Pitsch, Michael Sulyok, Rudolf Krska, Julian Weghuber (2020)  DNA barcoding for the identification of mold species in bakery plants and products. Food Chemistry Jul 15; 318:126501. 
  • Georg Sandner, Andreas S Mueller, Xiaodan Zhou, Verena Stadlbauer, Bettina Schwarzinger, Clemens Schwarzinger, Uwe Wenzel, Klaus Maenner, Jan Dirk van der Klis, Stefan Hirtenlehner, Tobias Aumiller, Julian Weghuber (2020)  Ginseng Extract Ameliorates the Negative Physiological Effects of Heat Stress by Supporting Heat Shock Response and Improving Intestinal Barrier Integrity: Evidence from Studies with Heat-Stressed Caco-2 Cells, C. elegans and Growing Broilers. Molecules 25:  4.  835. 
  • Clemens Röhrl, Flora Stübl, Martin Maier, Bettina Schwarzinger, Clemens Schwarzinger, Johannes Pitsch, Peter Lanzerstorfer, Marcus Iken, Julian Weghuber (2020)  Increased Cellular Uptake of Polyunsaturated Fatty Acids and Phytosterols from Natural Micellar Oil. Nutrients 12: 1. 150. 

2019

  • Roland Hager, Thomas Haselgrübler, Sandra Haas, Anna-Maria Lipp, Julian Weghuber (2020)  Fabrication, characterization and application of biomolecule micropatterns on cyclic olefin polymer (COP) surfaces with adjustable contrast. Biosensors 10: 1. 
  • Johannes Pitsch and Julian Weghuber (2019) Hydrophilic interaction chromatography coupled with charged aerosol detection for simultaneous quantitation of carbohydrates, polyols and ions in food and beverages. Molecules 24: 23. 
  • Renate Haselgrübler, Peter Lanzerstorfer, Clemens Röhrl, Flora Stübl, Jonas Schurr, Bettina Schwarzinger, Clemens Schwarzinger, Mario Brameshuber, Stefan Wieser, Stephan Winkler, Julian Weghuber (2019)  Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid exchange and lipid droplet motility. Scientific Reports 9: 1.
  • Alice König, Bettina Schwarzinger, Verena Stadlbauer, Peter Lanzerstorfer, Marcus Iken, Clemens Schwarzinger, Peter Kolb, Stephan Schwarzinger, Katharina Mörwald, Susanne Brunner, Otmar Höglinger, Daniel Weghuber, Julian Weghuber (2019)  Guava (Psidium guajava) fruit extract prepared by supercritical CO2 extraction inhibits intestinal glucose resorption in a double-blind, randomized clinical study. Nutrients 11:  1512.
  • Herbert Schneckenburger, Petra Weber, Michael Wagner, Sandra Enderle, Bernd Kalthof, Linn Schneider, Claudia Herzog, Julian Weghuber, Peter Lanzerstorfer (2019)  Combining TIR and FRET in Molecular Test Systems. International Journal of Molecular Sciences  20(3), 648. 

2018

  • Renate Haselgrübler, Verena Stadlbauer, Flora Stübl, Bettina Schwarzinger, Ieva Rudzionyte, Markus Himmelsbach, Marcus Iken, Julian Weghuber (2018) Insulin Mimetic Properties of Extracts Prepared from Bellis perennis.  Molecules 23(10), 2605.
  • Birgit Plochberger, Markus Axmann, Clemens Röhrl, Julian Weghuber, Mario Brameshuber, Benedikt K Rossboth, Sandra Mayr, Robert Ros, Robert Bittman, Herbert Stangl, Gerhard J Schütz (2018) Direct observation of cargo transfer from HDL particles to the plasma Membrane. Atherosclerosis 277: 53-59.
  • Lanzerstorfer Peter, Rechenmacher Elisabeth, Lugmayr Olivia, Stadlbauer Verenea, Höglinger Otmar, Vollmar Aandreas, Weghuber Julian (2018)  Effects of Various Commercial Whole-Grain Breads on Postprandial Blood Glucose Response and Glycemic Index. in Healthy Subjects Austin Journal of Clinical Medicine 5: 1. 1031.
  • Ulrike Müller, Flora Stübl, Bettina Schwarzinger, Georg Sandner, Marcus Iken, Markus Himmelsbach, Clemens Schwarzinger, Nicole Ollinger, Verena Stadlbauer, Otmar Höglinger, Tobias Kühne, Peter Lanzerstorfer, Julian Weghuber (2018)  In vitro and in vivo inhibition of intestinal glucose transport by guava (Psidium guajava) extracts. Molecular Nutrition and Food Research 62: 1870068. 
  • Yosuke Yoneyama, Peter Lanzerstorfer, Hideaki Niwa, Takashi Umehara, Takashi Shibano, Shigeyuki Yokoyama, Kazuhiro Chida, Julian Weghuber, Fumihiko Hakuno, Shin-Ichiro Takahashi (2018)  IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling eLIFE 7. 10.7554/eLife.32893.
  • Renate Haselgrübler, Flora Stübl, Verena Stadlbauer, Peter Lanzerstorfer, Julian Weghuber (2018)  An In-ovo Model for Testing Insulin-Mimetic Compounds. JoVE Journal of Visualized Experiments (134), e57237.

2017

  • G J Schütz, J Weghuber, P Lanzerstorfer, E Sevcsik (2017)  Protein Micropatterning Assay: Quantitative Analysis of Protein-Protein Interactions. Methods Mol Biol. 1550:  261-270. 
  • H Reyer, J Zentek, K Männer, I M I Youssef, T Aumüller, J Weghuber, K Wimmers, A Müller. (2017) Possible molecular mechanisms by which an essential oil blend from star anise, rosemary, thyme, and oregano and saponins increase the performance and ileal protein digestibility of growing broilers. Journal of Agricultural and Food Chemistry Aug 16;65(32):6821-6830.
  • R. Wagner, G. Stübiger, D. Veigel, M. Wuczkowski, P. Lanzerstorfer, J. Weghuber, E. Karteris, K. Nowikovsky, N. Wilfinger, C.F. Singer, R. Colomer, B. Benhamu, M.L. Lopez-Rodriguez, P. Valent, T.W. Grunt. (2017) Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells. Oncotarget 8(7):11600-11613.
  • Renate Haselgrübler, Flora Stübl, Katja Essl, Marcus Iken, Klaus Schröder, Julian Weghuber. (2017) Gluc-HET, a complementary chick embryo model for the characterization of antidiabetic compounds. PLoS ONE 12: 8. e0182788.

2016

  • Barbara Hohensinn, Renate Haselgrübler, Ulrike Müller, Verena Stadlbauer, Peter Lanzerstorfer, Gerald Lirk, Otmar Höglinger, Julian Weghuber. (2016) Sustaining elevated levels of nitrite in the oral cavity through consumption of nitrate-rich beetroot juice in young healthy adults reduces salivary pH. Nitric Oxide 60:10-15.
  • Florian Baumgart, Andreas Arnold, Konrad Leskovar, Kaj Staszek, Martin Fölser, Julian Weghuber, Hannes Stockinger, Gerhard J Schütz. (2016) Label density variation to probe membrane protein nanoclusters in dSTORM/PALM. Nature Methods Aug;13(8):661-4.
  • Verena Stadlbauer, Renate Haselgrübler, Peter Lanzerstorfer, Birgit Plochberger, Daniela Borgmann, Jaroslaw Jacak, Stephan M Winkler, Klaus Schröder, Otmar Höglinger, Julian Weghuber. (2016) Biomolecular Characterization of Putative Antidiabetic Herbal Extracts. PLoS ONE 11(1):e0148109.

2015

  • Eva Sevcsik, Mario Brameshuber, Martin Fölser, Julian Weghuber, Alf Honigmann and Gerhard J. Schütz. (2015) GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. Nature Communications 6:6969.
  • Jürgen Wruss, Gundula Waldenberger, Stefan Huemer, Pinar Uygun, Peter Lanzerstorfer, Ulrike Müller, Otmar Höglinger and Julian Weghuber. (2015) Compositional characteristics of commercial beetroot products and beetroot juice prepared from seven beetroot varieties grown in Uper Austria. Journal of Food Composition and Analysis 42:46-55.
  • Jürgen Wruss, Peter Lanzerstorfer, Stefan Huemer, Markus Himmelsbach, Harald Mangge, Otmar Höglinger, Daniel Weghuber and Julian Weghuber. (2015) Differences in pharmacokinetics of apple polyphenols after standardized oral consumption of unprocessed apple juice. Nutritional Journal 14(32).
  • Peter Lanzerstorfer, Yosuke Yoneyama, Fumihiko Hakuno, Ulrike Müller, Otmar Höglinger, Shin-Ichiro Takahashi and Julian Weghuber. (2015) Analysis of insulin receptor substrate (IRS) signaling dynamics on micro-structured surfaces. FEBS Journal 282(6).
  • Diana Zindel, Adrian J Butcher, Suleiman Al-Sabah, Peter Lanzerstorfer, Julian Weghuber, Andrew B Tobin, Moritz Bünemann, Cornelius Krasel. (2015) Engineered Hyperphosphorylation of the β2-adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization. Molecular Pharmacology 87(2):349-62.

2014

  • P. Lanzerstorfer,V. Stadlbauer, L. Chtcheglova, R. Haselgrübler, D.M. Borgmann, J. Wruss, P. Hinterdorfer, K. Schröder, S.M. Winkler, O. Höglinger, J. Weghuber. (2014) Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy. British Journal of Pharmacology 171(23). pp 5237-5251.
  • P Lanzerstorfer, D Borgmann, G Schütz, SM Winkler, O Höglinger, J Weghuber. (2014) Quantification and Kinetic Analysis of Grb2-EGFR Interaction on Micro-Patterned Surfaces for the Characterization of EGFR-Modulating Substances. PLoS ONE 9(3).
  • Lanzerstorfer P., Wruss J., Huemer S., Steininger A., Müller U., Himmelsbacher M., Borgmann D., Winkler S., Höglinger O., Weghuber J. (2014) Bioanalytical characterization of apple juice from 88 grafted and nongrafted apple varieties grown in Upper Austria. Journal of Agricultural and Food Chemistry 62 (5). pp 1047-1056.

2013

  • Reza Lornejad-Schäfer. (2013) Acetaminophen changes intestinal epithelial cell membrane properties, subsequently affecting absorbtion processes. Cellular Physiology and Biochemistry 32:431-447
  • P. Lanzerstorfer, D. Borgmann, A. Steininger, S. Schaller, M. Brameshuber, S. Sunzenauer, O. Hoeglinger, J. Weghuber.Analysis of Protein-Protein Interactions in Live Cells - The Micro-Patterning Approach. Basic Methods in Protein Purification and Analysis.   iConcept Press ISBN: 978-14775550-5-7.
  • Stefan Sunzenauer, Verena Zojer, Mario Brameshuber, Andreas Tröls, Julian Weghuber, Hannes Stockinger, Gerhard J Schütz. (2013) Determination of binding curves via protein micropatterning in vitro and in living cells. Cytometry A. 83(9):847-54.

2011

  • Julian Weghuber, Michael C. Aichinger, Mario Brameshuber, Stefan Wieser, Verena Ruprecht, Birgit Plochberger, Josef Madl, Andreas Horner, Siegfried Reipert, Karl Lohner, Tamás Henics, Gerhard J. Schütz. (2011) Cationic amphipatic peptides accumulate sialylated proteins and lipids in the plasma-membrane of eukaryotic host cells. Biochimica et Biophysica Acta - Biomembranes 1808(10):2581-90.

2010

  • Julian Weghuber, Stefan Sunzenauer, Mario Brameshuber, Birgit Plochberger, Clemens Hesch, Gerhard J Schuetz. (2010) In-vivo detection of protein-protein interactions on micro-patterned surfaces. JoVE Journal of Visualized Experiments March 19: 37.
  • Julian Weghuber, Stefan Sunzenauer, Birgit Plochberger, Mario Brameshuber, Thomas Haselgrübler, Gerhard J Schütz (2010) Temporal resolution of protein-protein interactions in the live-cell plasma membrane. Analytical and Bioanalytical Chemistry 397: 8. 3339-47.
  • Julian Weghuber, Mario Brameshuber, Stefan Sunzenauer, Manuela Lehner, Christian Paar, Thomas Haselgrübler, Michaela Schwarzenbacher, Martin Kaltenbrunner, Clemens Hesch, Wolfgang Paster, Bettina Heise, Alois Sonnleitner, Hannes Stockinger, Gerhard J. Schütz. (2010) Detection of protein-protein interactions in the live cell plasma membrane by quantifying prey redistribution upon bait micropatterning. Methods in Enzymology 472: 133-151.

2008

  • Mario Brameshuber, Michaela Schwarzenbacher, Martin Kaltenbrunner, Clemens Hesch, Wolfgang Paster, Julian Weghuber, Bettina Heise, Alois Sonnleitner, Hannes Stockinger, Gerhard J. Schutz. Reply to "Uncoupling diffusion and binding in FRAP experiments". Nature Methods 6: 3. 183-184. 2008.
  • Michaela Schwarzenbacher, Martin Kaltenbrunner, Mario Brameshuber, Clemens Hesch, Wolfgang Paster, Julian Weghuber, Bettina Heise, Alois Sonnleitner, Hannes Stockinger, Gerhard J. Schutz. (2008) Micropatterning for quantitative analysis of protein-protein interactions in living cells. Nature Methods 5: 12. 1053-1060.

Conference papers

  • Herbert Schneckenburger, Petra Weber, Michael Wagner, Sandra Enderle, Julian Weghuber, Peter Lanzerstorfer (2019) Combining TIR and FRET: from fluorescence microscopy to a multiwell reader system In: PROCEEDINGS OF SPIE, Advances in Microscopic Imaging II European Conferences on Biomedical Optics.

Wissenschaftliche Beiträge zu Forschungsthemen

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